So it is not a surprise that PPARγ plays important roles in CVDs including hypertension [17, 24, 25], atherosclerosis [26], HF [27], diabetic cardiomyopathy [11, 28], angiogenesis [29], valvular calcification [30], aortic aneurysm [31], restenosis following cardiovascular interventions [32], and ischemia/reperfusion (I/R) injury [33, 34]. The gene discussed is PPARG; the disease is diabetic cardiomyopathy.