BDKRB1 and early-onset autosomal dominant Alzheimer disease: Studies have shown BDKRB1 activation and/or increased expression in several pathological states, including infection [44], allergy [45], arthritis [46], cancer [47], chronic pain and inflammation [42, 48], diabetes mellitus [49], and neurological disorders, such as epilepsy, stroke, multiple sclerosis [50], and Alzheimer's disease [51].