There were no statistically significant factors explaining variability of leptin, adiponectin, visfatin/NAMPT, resistin, and TNF-α levels in breast cyst fluid in multiple, backward stepwise linear regression analysis, while IL-6 level in breast cyst fluids decreased by serum estradiol levels (β = −0.005; p < 0.05). This evidence concerns the gene NAMPT and breast cyst.