MT3 and esophageal squamous cell carcinoma: On the other hand, while MT3‐MMP expression in the horny pearl was seen in 41.2% (28/68) patients with moderately and well‐differentiated ESCC, MT3‐MMP positivity was detected in only 1 of 18 (5.5%) patients with poorly‐differentiated ESCC (P = 0.004 compared to the former, Table 1).