They also reported that a point mutation of the B7‐H4 NLS motif suppressed leptomycin B‐induced nuclear accumulation of B7‐H4 and abrogated B7‐H4‐mediated proliferation and cell cycle progression of HEK293 human embryonic kidney cells, whereas wild‐type B7‐H4 confers chemoresistance on RCC cell lines, indicating that nuclear localization of B7‐H4 might be crucial for its influence on cell proliferation and cell cycle progression 30. Here, VTCN1 is linked to renal cell carcinoma.