On the other hand, it is not clear that PD‐L1, B7‐H4 and VEGF could evade immune surveillance in the cooperative or independent manner by negatively regulating the immune system in ccRCC, and whether VEGF is the causal factor in release of PD‐L1 or B7‐H4 expressed by RCC to peripheral blood. The gene discussed is VTCN1; the disease is nonpapillary renal cell carcinoma.