First, the preoperative serum levels of PD‐L1, B7‐H4, and VEGF in ccRCC patients were significantly higher than those in the healthy controls, and the correlation of B7‐H4 or PD‐L1 with VEGF in ccRCC patients was established at their higher expression levels, in particular in metastatic disease, indicating that this correlation would have any disease‐related implications. This evidence concerns the gene VTCN1 and metastatic neoplasm.