VEGFA and neoplasm: For many tumors, hypoxia causes tumor cells, stromal cells, and normal cells to produce VEGF with immunosuppressive effects both locally and at distant sites, and creates a microenvironment of inhibitory inflammatory cells; the recruitment of myeloid‐derived suppressor cells (MDSC) and the induction of Treg cells by inhibiting DC maturation 33, 34, 35.