reported in 93 human hepatocellular carcinoma (HCC) patients that soluble B7‐H4 levels in patients were significantly higher than that in healthy controls; high sB7‐H4 levels were correlated with tumor differentiation, tumor invasion, tumor‐node metastasis stage, and poor overall survival; high sB7‐H4 levels were independent prognostic factors for overall survival 32. This evidence concerns the gene VTCN1 and neoplasm.