VEGFA and cancer: Many studies showed an anti-tumoural effect of BETi,19, 21, 22, 24 and recently it was found that JQ1 shows a typical behaviour of anti-angiogenic agents and, in fact, JQ1 can reduce tumour vascularization by suppressing VEGF stimulation.39 Angiogenesis is upregulated by hypoxia and supports tumour progression.7 Anti-angiogenic therapy is a major cancer treatment strategy used to treat eight solid tumour types.