LDHA and ovarian cancer: LDHA was reported to be downregulated by JQ1 in ovarian cancer,40 may be because of its regulation by MYC.41 Whereas JQ1 reduced the expression of oxidative phosphorylation, pentose phosphate pathway, TCA gene data sets but not glycolysis in TNBC cell line MDA-MB-231, in the ER+ cell line MCF-7, JQ1 increased TCA.