CXCR7 is a G protein-coupled receptor upregulated in breast cancer associated with worst outcome that mediates angiogenesis and metastasis.50 LOX is also upregulated in breast cancer and confers a poor prognosis, where it enables angiogenesis51 and disrupts bone homeostasis providing a favourable environment for metastatic cells from hypoxic ER− breast cancer.52 Taken together, this led us to the original suggestion that HIF targets can be divided into BET-dependent and BET-independent. This evidence concerns the gene ACKR3 and breast cancer.