MYC and neoplasm: Initially, studies described JQ1 effects as MYC-dependent.16, 18, 47 Although some studies reported MYC expression predicts JQ1 sensitivity, our results indicate other mechanisms are relevant; as JQ1 reduced tumour cell growth both in MYC-amplified (MCF-7 and HCC1806) and MYC-non-amplified cell lines (MDA-MB-231, Cal51 and SUM159).