A differential expression analysis showed 259 differentially expressed genes associated with SIRT2 expression, signaling pathways such as renin-angiotensin, complement and coagulation cascades was involved in SIRT2 pathogenicity and Gene sets like MAPK signaling pathway, VEGF signaling pathway and acute myeloid leukemia were upregulated in SIRT2high patients. This evidence concerns the gene VEGFA and acute myeloid leukemia.