REN and acute myeloid leukemia: A differential expression analysis showed 259 differentially expressed genes associated with SIRT2 expression, signaling pathways such as renin-angiotensin, complement and coagulation cascades was involved in SIRT2 pathogenicity and Gene sets like MAPK signaling pathway, VEGF signaling pathway and acute myeloid leukemia were upregulated in SIRT2high patients.