In both pT1M0 and pT1M1 tumours, a moderate-to-good positive correlation (r=0.4–0.7; Spearman's rank correlation coefficient) for HIF-1α and HIF-2α as well as co-expression of phospho-mTOR S2448 and phospho-S6RP S235/236 was found. The gene discussed is HIF1A; the disease is neoplasm.