These include distal-less homeobox 5 (DLX5; MIM 600028), distal-less homeobox 6 (DLX6; MIM 600030), deleted in split hand/split foot malformation 1 region (SHFM1; MIM 601285), and dynein cytoplasmic 1 intermediate chain 1 (DYNC1I1; MIM 603772) through its exonic enhancers (eExons) 15 and 17. So far, there are reports of eight families with deletion of DYNC1I1 and preserved DLX5/6 associated with ectrodactyly, the main manifestation of the SHFM1 syndrome [3]. This evidence concerns the gene DYNC1I1 and split hand-foot malformation.