Intriguingly, in three of the NSCLC specimens (samples 4, 5 and 7), the truncated TEAD4-S protein was the predominant isoform in normal tissues, but was almost completely eliminated in tumours, implying that the AS switch in TEAD4 could play a major role in the tumorigenesis of these patients. The gene discussed is TEAD4; the disease is neoplasm.