TRPV4 and neoplasm: A recent study implicated TRPV4 in tumor angiogenesis, as Florio Pla and coworkers reported AA-dependent TRPV4-mediated Ca2+ influx selectively drives cell migration via remodeling of the actin cytoskeleton in breast tumor endothelial cells but not in the control cells belonging to human dermal microvascular endothelial cell line22.