TNF and type 1 diabetes mellitus: Results from the pairwise case-control study demonstrated that environmental exposure to BDE47 was positively associated with human diabetes prevalence, which was strengthened by the animal experiment results showing that BDE47 could significantly increase high fasting glucose in rats and enrich T1D pathways with the involvement of some related genes, such as Tnf, Ins2, Adipoq, and Ednra. These results indicated that BDE47 might induce the disorder of glycometabolism and potentially result in the onset of diabetes.