Next, we investigated the possibility of crosstalk between Cbx7 and Hippo signalling pathway as the latter pathway is well known for its role in cell proliferation, apoptosis, metastasis and invasion of cancer cells13, Gene set enrichment analysis (GSEA) revealed a significant negative enrichment of Yes-associated protein (YAP)/Tafazzin (TAZ) target genes (identified by three independent studies14, 15, 16; Supplementary Table ST3–5) in Cbx7 overexpressed condition (Fig. 4A–C). This evidence concerns the gene TAFAZZIN and cancer.