Enhancement of O-GlcNAcylation by PUGNAc or siOGA induced the phosphorylation of Akt at ser-473 and increased the proliferation of thyroid anaplastic cancer cells35 whereas the increase of O-GlcNAcylated Akt conferred chemo-resistance in breast cancer-derived MCF-7 cells36. This evidence concerns the gene AKT1 and thyroid gland undifferentiated (anaplastic) carcinoma.