We report the results of single-variant and gene-based association tests performed in BIN1, CLU, CR1, PICALM, MS4A6A, ABCA7, EPHA1, CD33, and CD2AP in a cohort composed of 332 apparently sporadic and mainly late-onset AD cases and 676 elderly Caucasian controls from North America and the UK. This evidence concerns the gene EPHA1 and Alzheimer disease.