Moreover, in a similar way, ABCA1, whose LoF variants have been associated to AD (Kim et al., 2012, Nordestgaard et al., 2015), has been reported to be particularly enriched for low frequency and rare coding variants with an average 1.5-fold higher frequency in controls compared to LOAD cases and a modest protective effect in a Greek cohort (OR = 0.96–0.38; Lupton et al., 2014; Supplementary Table 12). This evidence concerns the gene ABCA1 and Alzheimer disease.