report an enrichment for common and low-frequency polymorphism with a modest protective role in ABCA7. Importantly, among the top 10 genetic variants identified in our study, 3 missense mutations (rs74176364, rs114782266, and rs117187003) have been described associated also to autism spectrum disorder, strongly pointing toward a functional role of these amino acid changes and suggesting a possible shared pathogenic mechanisms underpinning neurodegenerative and neurodevelopmental diseases (He et al., 2014). The gene discussed is ABCA7; the disease is autism spectrum disorder.