TRPM8 and osteosarcoma: TRPM8 expression in normal conditions is tissue-selective, while when TRPM8 is abnormally expressed, it has been observed in several different cancer tissues, such as prostatic, pancreatic, breast and colorectal ones, in urinary bladder and oral squamous cells, and in lung carcinoma, melanoma, neuroblastoma and osteosarcoma (Yee 2015).