VDAC mediates metabolic cross-talk between the mitochondria and the rest of the cell (Shoshan-Barmatz et al. 2010; Shoshan-Barmatz and Mizrachi 2012; Reddy 2013), is a key player in the regulation of mitochondria-mediated apoptosis and is implicated in cancer and neurodegenerative disorders (Shoshan-Barmatz et al. 2010; Shoshan-Barmatz and Golan 2012; Shoshan-Barmatz and Mizrachi 2012; Reddy 2013). Here, VDAC1 is linked to cancer.