SPG7 and cancer: Interestingly, downregulation of SPG7 expression, however only a minor one, can be observed in different cancer tissues (see Table 1): we performed an in silico analysis based on the Oncomine® Research Edition, a web application that integrates and unifies high-throughput cancer-profiling data across a large volume of cancer types, subtypes and experiments so that target expression can be assessed online, to compare expression of a given protein in several cancers compared to normal tissues.