ITPR3 and glioblastoma: Indeed, type 1 IP3R (i.e., IP3R1) expression is reduced and type 3 IP3R (i.e., IP3R3) expression is increased in human glioblastoma tissues compared to normal human brain, and inhibition of IP3R3 by caffeine reduces the migration, invasion and survival of glioblastoma cells (Kang et al. 2010).