Several studies have shown differences in the expression of VDAC between cancer cell lines and tissues with respect to the normal counterparts: high VDAC1 levels were observed in hepatoma, sarcomatous alterations (Yoo et al. 2009), non-small-cell lung cancer (NSCLC) cells (Brahimi-Horn et al. 2012), gastric cancer cells (Bai et al. 2011) and different cancer types, such as thyroid, lung, cervix, ovary, pancreas, melanoma and glioblastoma cancers. This evidence concerns the gene VDAC1 and melanoma.