TMBIM6 and neoplasm: In addition, other proto-oncogenes as well as tumor suppressors, such as Akt/protein kinase B (PKB) (Chan and Tsichlis 2001), Bax inhibitor-1 (BI-1) (Li et al. 2007a; Eckenrode et al. 2010) and K-ras-induced actin-interacting protein (KRAP) (Fujimoto et al. 2011), modulate cancer development by acting on Ca2+ fluxes mediated by the IP3Rs (Akl and Bultynck 2013).