TRAP1 and neoplasm: In particular, the oncogenic TRAP1 was shown to interact with succinate dehydrogenase (SDH), inhibiting succinate oxidation and inducing a pseudohypoxic response (i.e., HIF1 activation in normoxic conditions) (Sciacovelli et al. 2013), but also by shielding tumor cells from ROS-induced PTP opening and death.