MRS2 and cancer: In agreement, an augmented expression of the mrs2 gene has been reported by comparing normal and cancer organs as shown in Table 4: a general increase of around two-three-fold (but in testis tumor a 17-fold increase) has been observed in blood, skin, ovarian, kidney, breast, lung and bladder tumors when compared to the normal tissues, meaning that it would be worthwhile to further deepen our understanding of the possible role of mitochondrial Mg2+ fluxes in cancer development (see Table 4 and the references therein).