Finally, we applied hapLOHseq to WES experiments on two adenomas from a patient with familial adenomatous polyposis (FAP), a cancer syndrome resulting from a germline mutation in APC (5q), where the acquired second somatic mutation (or ‘hit’; Knudson, 1971) may be an LOH event (Galiatsatos and Foulkes, 2006). The gene discussed is APC; the disease is Familial adenomatous polyposis.