To determine whether altering dermal Wnt/β-catenin signalling would affect HF formation in the wound bed, we specifically deleted or activated β-catenin in fibroblasts by crossing Ctnnb1flox/flox or Ctnnb1+/flox(ex3) with PDGFRaCreERt2×tdtomato mice and applying tamoxifen after birth (P0 and P3) (Mastrogiannaki et al., 2016). The gene discussed is CTNNB1; the disease is hydrops fetalis.