The emerging role of SDH in cancer, neurological disorders [16], [17], [18], [19], [21], [57], [68], cell signalling [12], [13], [14], [15] (including stabilization of transcriptional factor HIF-1α [19]), immune response [20] and cardiovascular conditions [22], [23] highlights the need to determine if OAA has a regulatory function. The gene discussed is HIF1A; the disease is nervous system disorder.