CCR3 and allergic disease: The recruitment of eosinophils arises from the combined action of a number of cellular and molecular signals, including eotaxin.2, 3 Eotaxin-1 binds with high affinity to CC chemokine receptor 3, which is expressed by a variety of inflammatory cells.4, 5, 6 Blocking eotaxin or CCR3 has been proposed as a new approach to allergy immunotherapy.7, 8 However, more information about the interaction between the ligands and their receptors is required.