Using the seipin-KO mice with reduction of PPARγ, we observed that seipin deficiency elevated the activity of GSK3β to enhance the production of TNF-α and IL-6, which in turn triggered and strengthened the Aβ25–35-induced inflammatory responses leading to the death of neuronal cells and the spatial cognitive deficits. The gene discussed is GSK3B; the disease is Cognitive impairment.