For example, a high baseline CRP might suggest that longer treatment duration is necessary (importantly, a high baseline CRP appears to be associated with an increased likelihood of death in active TB [8]) Equally, the failure of CRP to normalise with treatment may indicate that therapy is less effective than it should be (e.g. due to drug failure or poor adherence) - triggering increased clinical input and re-assessment. The gene discussed is CRP; the disease is tuberculosis.