AGER and respiratory failure: It has been previously suggested that epithelial cell-derived MVs are upregulated in BALF in patients with ARDS at 6 hours after intubation for respiratory failure,12 although these MVs were identified by expression of the receptor for advanced glycation end products (RAGE), and would likely represent a mixture of cell origins as various lung cells express RAGE.34 CD11b+/Ly6G+ MVs were only apparent at 4 hours in our model of LPS-induced ALI, suggesting that these are MVs produced by infiltrating neutrophils.