AKT2 and Infertility: Intriguingly, while Dedd−/− female mice cannot produce any progeny, and while IL-11Rα−/− female mice are severely infertile, any single knockout of either Akt1, Akt2, Akt3, or cyclin D3 does not cause complete infertility, suggesting the importance of Dedd as a master regulator in the upstream of these multiple proteins’ network.