HOPX and neoplasm: These results suggest that the genes in the tumor-associated stroma/mesenchymal module which are downregulated in both Hopx−/− mice and Wnt-inhibited Hopx−/− mice are good candidates as downstream targets of HOPX. Figure 7d shows those 32 potential targets of HOPX. The purple-colored genes are the potential targets that are downregulated in Hopx−/−mice and their expression does not change significantly (|FC change| ≤0.55) upon Wnt inhibition.