TCF4 and cancer: Module 5 contains known EMT inducers ZEB1, SNAI2, and TCF4 (E2.2) [78], as well as multiple other genes known to be important in focal adhesion [79], extracellular matrix interaction [80], extracellular matrix organization [81], and markers of cancer-associated fibroblasts (PDGFRB, PDGFRA) [82] (see Additional file 8: Table S3).