When we apply INSPIRE to nine gene expression datasets from ovarian cancer studies (Fig. 2c), we identify a novel tumor-associated stromal marker, HOPX, which additional analyses suggest may be a molecular driver for a conserved module in the network that contains known epithelial-mesenchymal transition (EMT) inducers and is significantly associated with percent stroma in ovarian tumors from The Cancer Genome Atlas (TCGA). Here, HOPX is linked to neoplasm.