APOE and metabolic syndrome: As other studies have shown that the influence of depressive symptoms may be greater for individuals with the apolipoprotein E4 (APOE ε4) allele compared to those without the allele, for example, on cognitive functioning [38], we also tested the possibility that the APOE ε4 allele modifies the relation between depressed mood and MetS, i.e. interaction terms (APOE ε4*depressive symptoms, APOE ε4*antidepressant medication use) were calculated and added to the basic models.