Moreover, unlike CD4+Foxp3+ Tregs, which are generated in the thymus, suppressive CD8+Foxp3+Tregs appear after primary antigen stimulation, suggesting that these cells are amplified by TCR stimulation, as verified in patients with inflammatory diseases such as autoimmune type 1 diabetes and multiple sclerosis [25, 26]. The gene discussed is CD4; the disease is multiple sclerosis.