CD274 and metastatic malignant neoplasm in the lymph nodes: In multivariate Cox analysis, factors related to shorter DFS included higher T stage (hazard ratio: 10.21, 95 % CI 1.306–79.90, p = 0.027) and lymph node metastasis (hazard ratio: 3.918, 95 % CI 1.254–12.24, p = 0.019), while factors related to shorter OS were higher T stage (hazard ratio: 6.317, 95 % CI 1.413–28.23, p = 0.016), lymph node metastasis (hazard ratio: 3.564, 95 % CI 1.304–9.740, p = 0.013), and PD-L1 (28-8) negativity in immune cells (hazard ratio: 5.112, 95 % CI 1.110–23.54, p = 0.036, Table 7).