Conversely, the presence of a lower HbA1C in the orally treated patients (except those having sulfonylureas) is unlikely due to more frequent episodes of hypoglycaemia as metformin and DPP-4 inhibitors do not cause hypoglycaemia and the risk for hypoglycaemia is very low with the use of glinides, especially in CKD stages lower than stage G4 [21]. This evidence concerns the gene DPP4 and chronic kidney disease.