We have previously reported that CUE domain containing 2 (CUEDC2) not only promotes the ubiquitination and degradation of the progesterone receptor (Zhang et al, 2007; Pan et al, 2011) but also plays indispensable roles in inflammation and cancer (Li et al, 2008; Gao et al, 2011). The gene discussed is CUEDC2; the disease is cancer.