Overexpression of adiponectin in genetically engineered mice and stimulators of adiponectin secretion such as thiazolidinediones [33] and fibroblast growth factor 21 [34] are associated with reduced bone density, heart damage (left ventricular hypertrophy), weight gain from promoting adipogenesis and angiogenesis [35], and infertility [36]. This evidence concerns the gene ADIPOQ and left ventricular hypertrophy.