Therefore, AdipoR1 and AdipoR2 activation appears to contribute to protection against CKD progression including in DN, although AdipoR1 is more highly expressed than AdipoR2 in kidneys and the relationship between renal expression of renal AdipoR1 and AdipoR2 and renal function is biphasic. This evidence concerns the gene ADIPOR2 and liver dysplastic nodule.