GPC3 and hepatocellular carcinoma: A statistically significant correlation with 5-year survival rate based on COX regression univariate analysis, more interesting is GPC-3 level and HBV infection identified as independent predictive factors for worse HCC outcome, that is, HCC patients with higher GPC-3 level, and shorter survival time compared with those lower or no expression, suggesting that GPC-3 not only be a specific biomarker but also be an independent prognostic factor for HCC.