GPC3 and hepatocellular carcinoma: In conclusion, the up-regulation of oncofetal antigen GPC-3 regulates the malignant transformation of hepatocytes, promotes cell proliferation, and effects on the survival rate of HCC patients through its downstream canonical or noncanonical Wnt pathway that should provide new mechanism insight into molecular-targeted therapy for HCC [27, 28] because of contributing to HCC growth and related to HBV infection.