ANRIL can talk with polycomb repressive complex-1 (PRC1) and -2 (PRC2) to form heterochromatin surrounding INK4b-ARF-INK4a locus and therefore repress the expression of such tumor-suppressor genes as p15INK4b and p16INK4a [8]. Here, CDKN2B-AS1 is linked to neoplasm.