POLR1H and hepatocellular carcinoma: In summary, this large case-control study revealed that multiplicative interactions of ZNRD1-AS1 SNPs with HBV genotypes significantly affect HCC risk and suggested that HBV genotypes and ZNRD1-AS1 SNPs (rs3757328, rs6940552 and rs9261204) may serve as susceptibility biomarkers for the risk of HBV-related HCC.