In the model filled with interested variables and clinically important prognosticators, including gender, tumor grade, stage, and lower ureteral tumors, TP53 mutations other than A:T to T:A transversions still presented as an independent variable predicting a higher risk (HR: 8.4 and 3.7, p < 0.001 and = 0.01, respectively) of bladder recurrence compared with wild-type TP53 and TP53 mutations with A:T to T:A transversions. This evidence concerns the gene TP53 and neoplasm.