By stratifying UTUC patients according to TP53 mutation patterns, we observed that patients with an A:T to T:A transversion in the TP53 gene had a higher risk of contralateral upper urinary tract recurrence, and those with non- A:T to T:A transversion mutations had more bladder tumor recurrences and metastases than the other two groups. The gene discussed is TP53; the disease is renal pelvis/ureter urothelial carcinoma.