What's more, low Smad4 expression level was also negatively correlated with pT stage (P = 0.004), pN stage (P = 0.006), pM stage (P = 0.032), and AJCC stage (P = 0.044), not with patients’ age (P = 0.773), gender (P = 0.779), tumor location (P = 0.124), and differentiation (P = 0.255) (Table 1A). Here, SMAD4 is linked to neoplasm.