SMAD4 and colorectal carcinoma: Here, we identified a novel miRNA, miR-20a-5p, which targeted smad4 3′-UTR, and verified that 1) high miR-20a-5p expression promoted the invasion and metastasis of CRC cells and induced EMT of CRC cells by directly binding to the 3′-UTR of Smad4; 2) most importantly, we also revealed that miR-20a-5p was upregulated in CRC tissues and high miR-20a-5p expression predicted the poor prognosis.