Furthermore according to the authors, the presence of PIA (proliferative inflammatory atrophy) precursor HGPIN and prostate cancer charged to the prostatic parenchyma, involves the presence of abnormal values of GSTP1 (gene coding for glutathione S-transferase), GSTA1 (gene coding for glutathione S-transferase A1) and COX-2 (enzyme determining the conversion of arachidonic acid (AA) in the prostaglandin endoperoxide H2 precursor of PGD2, PGE2, PGF2α, PGI2 and thromboxane A2). The gene discussed is PTGS2; the disease is Familial prostate cancer.