The relationship between prostate cancer and the intake of green tea and then directly the action of polyphenols (in particular ‘epigallocatechin-3-gallate or EGCG) is expressed at different levels in prostate cancer etiology by modulating different pathways linked to inflammation chronic (action on NF-kB and COX-2) and also the metabolic syndrome itself (IGFR). The gene discussed is NFKB1; the disease is Familial prostate cancer.