SPARC and neoplasm: The anti-tumor action of curcumin seems to be explained, according to Killian et al. (43,) also by the reduction process of metastatization of the cancer: in murin model it has been shown that in cell lines treated with curcumin there is a reduction of the genetic factors that promote the formation of lung metastases (SPARC (osteonectin), COX2 (PTGS2, prostaglandin-endoperoxidesynthase 2), ALDH3A1 (aldehyde dehydrogenase-3 family member A1) and EFEMP (EGF-containing fibulin-like extracellular matrix) through a reduction of the overexpression of the proteins CXCL1 and-2).