We also performed targeted ultra-deep sequencing of these CARD11 and CREBBP mutations and could detect residual small subclones in both relapsed CARD11 samples (AF: 0.06% and 0.02%; median coverage: 430,000X) and two CREBBP samples (AF: 0.2% and 0.1%; median coverage: 500,000X). Here, CREBBP is linked to atrial fibrillation.