Fontana et al. reported that in therapy-resistant neuroblastoma, an increased miR-17-5p expression causes the downregulation of p21 and the tumor suppressor gene Bcl-2-interacting mediator (BIM) of cell death, which could be antagonized by miR-17-5p AS ODN, representing a novel oncogenic pathway to explain neuroblastoma progression and its resistance to therapy [25]. This evidence concerns the gene CDKN1A and neuroblastoma.