Given that an individual miRNA may repress multiple mRNAs, it is possible that other genes, e.g. PTEN, are simultaneously targeted by miR-26a, which synergizes with PTPN13 silencing to maintain survival and proliferation of NSCLC cells in the presence of EGFR-TKIs [8, 18]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.