These findings suggest that LOXL2 over-expression might be a poor prognostic factor in pancreatic cancer, based on evidence that LOXL2 expression in pancreatic cancer cells might contribute to metastasis in a clinical setting, and further suggest that inhibition of LOXL2 might provide a survival benefit to patients with pancreatic cancer. This evidence concerns the gene LOXL2 and familial pancreatic carcinoma.