Results showed higher levels of dimethylated H3K36 protein levels in 293T cells transfected with the wild type WHSC1L1 than those with enzyme-inactive WHSC1L1 (Figure 3B), indicating that WHSC1L1 regulates the levels of H3K36 dimethylation in SCCHN cells. Here, NSD3 is linked to head and neck squamous cell carcinoma.