We confirmed downregulation of CDC6 and CDK2 at the mRNA, as well as at the protein level in three SCCHN cell lines, YD-10B, UD-SCC-2 and HN13 cells, transfected with two WHSC1L1 specific siRNAs (Figure 3D). The gene discussed is CDC6; the disease is head and neck squamous cell carcinoma.