Interestingly, amongst the top two most frequently altered enzyme families in SCCHN were the NSD (nuclear SET-Suppressor of variegation 3-9, Enhancer of zeste and Trithorax-domain, NSD1, NSD2/WHSC1/MMSET, NSD3/WHSC1L1) family of protein lysine methyltransferases (PKMTs) which are genetically altered in 28% of SCCHN, implying a critical role for these enzymes in SCCHN oncogenesis [3, 4]. The gene discussed is NSD1; the disease is head and neck squamous cell carcinoma.