More recently, Shen et al [21] showed that BRD4, which is necessary for the maintenance of the malignant phenotype of AML, requires the PWWP domain of the short WHSC1L1 isoform as an adapter protein which links BRD4 to the CHD8 chromatin remodeler, while all of these proteins are co-localized in the AML genome and are released from super-enhancer regions through BET bromodomain chemical inhibition. Here, CHD8 is linked to acute myeloid leukemia.