We then proceeded to assess correlations of WHSC1L1 expression with various clinicopathological parameters, such as overall and progression-free survival, age, gender, primary site, tumor size (T), nodal stage (N), TNM stage, grade, smoking history and human papilloma virus status in SCCHN patients with local or locoregionally advanced disease who were treated with either surgery with or without adjuvant chemoradiation, or definitive chemoradiation. Here, NSD3 is linked to neoplasm.