Although it is currently unclear how CREB signaling regulates EMT in CRC cells and subsequent migration, several previous studies have suggested that CREB signaling influences TGF-β signaling in pancreatic cancer cells and fibroblast [51, 56] and that EP300 can act as a transcriptional co-activator to regulate E-cadherin expression. This evidence concerns the gene CDH1 and colorectal carcinoma.