It is noteworthy that Chiou et al. reported a paracrine feedback regulatory loop between miR142-3p and IL-6 in GBM cells [33], in which IL-6 suppresses miR142-3p expression through increasing its promoter methylation, while miR142-3p inhibits IL-6 expression and secretion by directly targeting IL-6 3′UTR. Here, IL6 is linked to glioblastoma.