To further dissect the microenvironmental change, we treated the GBM cells with the conditioned medium (C.M.)comparing to serum-free medium (S.F.), suggesting the secretory fact of IL-6 in stressful MSI1-overexpressed GBM cells while anti- IL-6 could effectively neutralize the effect (Figure 6E-6G). The gene discussed is IL6; the disease is glioblastoma.