As shown, immune system associated GO items (regulation of CD8-positive, alpha-beta T cell differentiation) and KEGG pathways (Primary immunodeficiency) were enriched in the 182 HH-lncRNAs (Figure 2D, 2E), indicating these HH-lncRNAs may play important roles in the pathologic process of HBV-related HCC. This evidence concerns the gene CD8A and hepatocellular carcinoma.