In agreement with the notion that the antineoplastic effect of L-NAME is linked to inhibition of NOS, we previously demonstrated that L-NAME elevated blood pressure in a similar KrasLSL-G12D/+;Trp53LSL-R172H/+ mouse model of pancreatic cancer [21], validating NOS inhibition in vivo [33, 34]. This evidence concerns the gene NOS2 and familial pancreatic carcinoma.