CD4 and AIDS: Though rank distribution of episode duration was not statistically different between the groups, a higher percent of episodes exceeding 10 days (6% vs 2.8%, p = 0.01) and 20 days (2.8% vs 0.2%, p<0.001) were noted in the simulations of the group with CD4+ T cell <200/μL (Fig 6D). These exceptionally long episodes were notable for multiple HSV-2 re-expansion phases and wide spatial dissemination of virus (S2 Movie), and correspond to severe persistent lesions in patients with AIDS.