The role of vitamin D in adipokine activity is a current active area of research, Roth et al. has investigated the effect of vitamin D deficiency on adiponectin, leptin, resistin, TNF-α, and IL-6 [39], and it may worsen NAFLD by up-regulation of hepatic inflammatory and oxidative stress genes. The gene discussed is LEP; the disease is metabolic dysfunction-associated steatotic liver disease.