On the other hand, Goto et al. evaluated the growth plates of the femur and detected large amounts Cathepsin D suggesting that this enzyme is necessary for osteoclastic resorption.[16] In another study, Goto et al. showed that Cathepsin D has an active indirect role in osteoclastic resorption.[17] Demertzis et al. carried out a study on giant cell tumor and reported that all the giant cells in all samples expressed this enzyme. This evidence concerns the gene CTSD and giant cell tumor.