It has been shown miR-1 can suppress metastasis in HNSCC by targeting TAGLN2, a gene which mediates cell migration and invasion.[53] Let-7d, a member of the let-7 family of miRNAs acts as a tumor suppressor, most likely via targeting RAS.[54] A reduction of let-7d expression in OSCC tissues has been reported. This evidence concerns the gene TAGLN2 and head and neck squamous cell carcinoma.