ITGA6 and cancer: Similarly, miR-1 down-regulation was observed in other types of cancer such as lung cancer.[105] A previous study indicated that miR-29 was down-regulated in breast cancer; miR-29 has an essential role in inhibiting growth of breast cancer cells via down-regulation of B-Myb.[106] But in HNSCC tissue, the target genes of mir-29 are LAMC2 and ITGA6.[58] The miR-34 family may inhibit invasion and metastasis in different cancer types.