TWIST1 and neoplasm: In addition, MET is important for the final stage of metastasis when the extravasated cancer cells revert to epithelial cells and proliferate as a secondary tumor in the metastatic site.[28] Some transcription factors are the inducers of EMT and tumor metastasis including, Snail, Slug, Twist, ZEB1, and ZEB2.[29] Several miRNAs inhibit EMT such as miR-573,[30] and miR-33b.[31] Overexpression of miR-7 also suppresses migration and invasion and partially reverses EMT via targeting IGF1R in gastric cancer.