For example in HNSCC, it acts via IGFIR and mTOR, though in cervical cancer the target gene is Tribbles (TRIB2) which controls the specificity of the activation of mitogen-activated protein kinases (MAPK).[112] miR-138 also targets different genes in human colorectal cancer (Twist 2) compared with HNSCC (GNAI2, RhoC, and ROCK2).[113] miR-10b was the first link between metastasis and miRNAs indicated in breast cancer. The gene discussed is IGF1R; the disease is breast carcinoma.